该杂志发表了关于细胞、分子和结构生物学、发育生物学、细胞生理学和进化的所有方面的原始研究文章和评论。它将发表文章或评论，有助于从分子、细胞和组织的尺度和生物体理解活物质组织的基本生化和生物物理原理。这包括对理解生物化学和生物物理机制的贡献，关于基本细胞和组织功能的结构-功能关系，发育，发育/进化关系，形态发生，干细胞生物学，疾病细胞生物学，植物细胞生物学的贡献，以及对理解细胞器、细胞和组织水平的综合过程的贡献。利用高分辨率成像、活体成像、定量细胞生物学和集成生物学等方法作出贡献;鼓励使用创新的遗传和表观遗传技术、体外组织工程、细胞、组织和综合功能分析、定量生物学和建模来展示原始生物学原理。该杂志特别欢迎侧重于细胞生物学与发育生物学、物理学、力学和化学之间的接口方法的贡献。细胞功能的任何方面都可以提出理论和生物物理模型。方法的描述将被考虑，但它们的有效性应该由一个或多个应用程序来证明。欢迎在细胞和分子生物学、发育或细胞生理学方面具有影响的“组学”研究。期刊还发布了一个名为Scientiae论坛的专门讨论和一般兴趣版块，其中包括以下主题的文章:模型和推测，细胞结构和功能的所有方面，旨在向在不相关领域工作的科学家开放特定主题的底稿综述，以及将当前生命科学研究置于其历史背景下的细胞生物学历史。
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The journal publishes original research articles and reviews on all aspects of cellular, molecular and structural biology, developmental biology, cell physiology and evolution. It will publish articles or reviews contributing to the understanding of the elementary biochemical and biophysical principles of live matter organization from the molecular, cellular and tissues scales and organisms.This includes contributions directed towards understanding biochemical and biophysical mechanisms, structure-function relationships with respect to basic cell and tissue functions, development, development/evolution relationship, morphogenesis, stem cell biology, cell biology of disease, plant cell biology, as well as contributions directed toward understanding integrated processes at the organelles, cell and tissue levels. Contributions using approaches such as high resolution imaging, live imaging, quantitative cell biology and integrated biology; as well as those using innovative genetic and epigenetic technologies, ex-vivo tissue engineering, cellular, tissue and integrated functional analysis, and quantitative biology and modeling to demonstrate original biological principles are encouraged.The journal welcomes, in particular, contributions focusing on approaches at the interface between cell biology and developmental biology, physics, mechanics and chemistry. Theoretical and biophysical models on any aspect of cell function can be submitted. Descriptions of methods will be considered but their validity should be demonstrated by one or more applications. “–omics” studies with impact in cellular and molecular biology, development or cell physiology are welcome.The Journal also publishes a specific discussion and general interest section called Scientiae Forum, that will include articles on the following topics: Models and Speculations, on all aspects of cell structure and function, Primer reviews aimed at opening-up specific topics to scientists working in unrelated fields of interest, and History of Biology of the Cell that will situate the present research in the life sciences within its historic context.
