一般和比较内分泌学是专门从事基础内分泌研究。该杂志强调基础研究，偶尔也会对某个特定领域或问题进行简要的评论。该杂志根据编辑的意见为每篇文章提供一个免费的彩色版。研究领域包括:激素作用的细胞机制;脊椎动物和无脊椎动物内分泌系统的功能、发育和进化方面;神经内分泌学;生殖生物学。
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General and Comparative Endocrinology is devoted to basic endocrinological research. Emphasizing fundamental research, the journal also features occasional brief reviews that deal with a particular field or problem. The journal offers one free color plate per article at the discretion of the editors. Research Areas include: Cellular mechanisms of hormone action; Functional, developmental, and evolutionary aspects of vertebrate and invertebrate endocrine systems; Neuroendocrinology; Reproductive biology.
